INDUCTION OF PUBERTY - LONG-TERM TREATMENT WITH HIGH-DOSE LHRH

被引：30

作者：

BROOK, CGD

DOMBEY, S

机构：

[1] MIDDLESEX HOSP, LONDON W1N 8AA, ENGLAND

[2] HOECHST PHARMACEUT, HOUNSLOW, MIDDLESEX, ENGLAND

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 01期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb03049.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gonadotropin releasing hormone 500 .mu.g was administered twice daily to 4 patients (2 male, 2 female) with hypogonadotropic hypogonadism due to LHRH [luteinizing hormone releasing hormone] deficiency, for a minimum of 1 yr. Despite initially encouraging biochemical responses and physical changes in all 4 patients, gonadotropin responsiveness waned, sex steroid levels were not maintained and pubertal development did not occur. This diminishing responsiveness appears to be a severe limitation on the use of LHRH as a therapeutic agent.

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页码：81 / 87

页数：7

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