TRANSFORMATION OF ARACHIDONIC-ACID INTO 12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID BY MOUSE PERITONEAL-MACROPHAGES

被引：45

作者：

RIGAUD, M

DURAND, J

BRETON, JC

机构：

[1] Laboratoire de Biochimie, Faculté de Médecine, 87300 Limoges Cedex

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 573卷 / 02期

关键词：

(Mouse peritoneal macrophage); Arachidonic acid; Hydroxyeicosatetraenoic acid;

D O I：

10.1016/0005-2760(79)90074-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse peritoneal macrophages were incubated at 37°C for 30 min with arachidonic acid (all-cis-5,8,11,14-eicosatetraenoic acid). Oxygenation of arachidonic acid in mouse peritoneal macrophages occurs by two major pathways: fatty acid cyclooxygenase and lipoxygenase. The major metabolite of the latter is 12-hydroxy-5,8,10,14-eicosatetraenoic acid which was identified by gas liquid chromatography on high resolution glass capillary column and mass spectrometry. © 1979.

引用

页码：408 / 412

页数：5