THE EFFECT OF A FISH OIL ENRICHED DIET ON OXYGEN-TOXICITY AND LIPID-PEROXIDATION IN MICE

被引:12
作者
BURNS, A
LIN, YG
GIBSON, R
JAMIESON, D
机构
[1] UNIV NEW S WALES,SCH PHYSIOL & PHARMACOL,POB 1,KENSINGTON,NSW 2033,AUSTRALIA
[2] FLINDERS UNIV,MED CTR,DEPT PEDIAT,BEDFORD PK,SA 5042,AUSTRALIA
关键词
D O I
10.1016/0006-2952(91)90445-B
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Mice were fed a chow diet or diets enriched in fish oil, sunflower oil or beef tallow for 3 weeks. Fatty acid analysis was carried out in samples of plasma, brain and lungs from these animals and large changes were found in plasma and lungs with relatively small dietary-induced changes in brain tissue. Bleeding times were increased very significantly in the fish oil group, and slightly increased in the sunflower oil group. Endogenous lipid peroxidation (measured as thiobarbituric acid reactive substances) was unchanged in lung and brain, but lung tissue from fish oil fed mice produced more lipid peroxides in vitro during incubation at 37-degrees than those of other dietary groups. Mice fed the four different diets were exposed to hyperbaric oxygen at 618, 585 and 515 kPa and convulsive activity and lung damage was recorded. No dietary-induced alterations in susceptibility to oxygen toxicity were found.
引用
收藏
页码:1353 / 1360
页数:8
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