HELIX-LOOP-HELIX GENES TRANSLOCATED IN LYMPHOID LEUKEMIA

被引：48

作者：

VISVADER, J

BEGLEY, CG

机构：

[1] Institute of Medical Research, Post Office Royal Melbourne Hospital, Parkville, Vic. 3050, J. Visvader and C.G. Begley are at Walter and Eliza Hall

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 09期

关键词：

D O I：

10.1016/0968-0004(91)90137-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new class of DNA-binding proteins with a helix-loop-helix (HLH) structure has recently been described. Many of these transcriptional regulators are known to play a central role in cell-specification and differentiation processes. Four members of the HLH family are now implicated in the development of human lymphoid malignancies as a result of aberrant expression following chromosomal translocation events. This review focuses on two of these family members: SCL and LYL-1.

引用

页码：330 / 333

页数：4

共 30 条

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