ANALYSIS OF VANCOMYCIN TIME-KILL STUDIES WITH STAPHYLOCOCCUS SPECIES BY USING A CURVE STRIPPING PROGRAM TO DESCRIBE THE RELATIONSHIP BETWEEN CONCENTRATION AND PHARMACODYNAMIC RESPONSE

被引：91

作者：

ACKERMAN, BH ^{[1
]}

VANNIER, AM ^{[1
]}

EUDY, EB ^{[1
]}

机构：

[1] UNIV ARKANSAS, SCH MED, DEPT PATHOL, LITTLE ROCK, AR 72205 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 08期

关键词：

D O I：

10.1128/AAC.36.8.1766

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mono- and biexponential killing curves for vancomycin over a 2- to 50-mu-g/ml concentration range were generated for 11 Staphylococcus aureus isolates and 12 coagulase-negative Staphylococcus species in the logarithmic phase of growth. Nonlinear least-squares regression of the initial growth rate and disappearance were not significantly different for lower or higher concentrations of vancomycin in broth.

引用

页码：1766 / 1769

页数：4

共 27 条

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