CALCIUM ALGINATE BEADS AS CORE CARRIERS OF 5-AMINOSALICYLIC ACID

被引:51
作者
LIN, SY [1 ]
AYRES, JW [1 ]
机构
[1] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331
关键词
CALCIUM ALGINATE BEADS; SPRAY COATING; 5-AMINOSALICYLIC ACID; ACID PRETREATMENT;
D O I
10.1023/A:1015887318767
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The utilization of calcium alginate beads as core carriers for delayed dissolution followed by burst release as a potential method of intestinal site specific drug delivery was investigated. 5-Aminosalicylic acid was spray-coated on dried calcium alginate beads and then coated with different percentages of enteric coating polymer and/or sustained-release polymer. Beads coated with more than 6% (w/w) methacrylic copolymer plastisized with dibutyl sebacate and triethyl citrate resisted release in 2-hr acid fluid challenge and allowed immediate dissolution upon transfer to simulated intestinal fluid. With 6% (w/w) methacrylic copolymer on top of 4% (w/w) ethylcellulose polymer, the major portion of drug did not release in 2 hr of acid treatment or the next 3 hr of simulated intestinal fluid treatment. This dosage form provides the possibility to deliver drug to the lower intestinal tract with minimal early release, followed by sustained release in the color.
引用
收藏
页码:1128 / 1131
页数:4
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