WELCOME TO THE FAMILY - THE ANTI-MULLERIAN HORMONE-RECEPTOR

被引：23

作者：

GROOTEGORD, JA

BAARENDS, WM

THEMMEN, APN

机构：

[1] Department of Endocrinology and Reproduction, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, 3000 DR Rotterdam

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1994年 / 100卷 / 1-2期

关键词：

ANTI-MULLERIAN HORMONE; SERINE/THREONINE KINASE RECEPTORS; GONAD; SEX DIFFERENTIATION; TESTIS; SERTOLI CELL;

D O I：

10.1016/0303-7207(94)90274-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Anti-mullerian hormone (AMH) is a member of the superfamily of peptide growth/differentiation factors which includes the activins and TGF-beta s. The putative AMH type II receptor, which was cloned recently (Baarends et al., 1994), is a member of the superfamily of transmembrane serine/threonine kinase receptors. In hypothetical evolutionary relationship dendrograms, both AMH and its putative receptor take isolated positions relative to their respective family members. The prenatal expression pattern of this putative AMH receptor is in accordance with the expected endocrine action of AMH on the mesenchymal cells located adjacent to the mullerian duct, and with known effects of AMH on gonadal differentiation. Postnatal expression of mRNA encoding this receptor in granulosa and Sertoli cells provides a new stimulus to study possible functions of AMH in the gonads.

引用

页码：29 / 34

页数：6

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