QUINAZOLINONES-1 - DESIGN AND SYNTHESIS OF POTENT QUINAZOLINONE-CONTAINING AT(1)-SELECTIVE ANGIOTENSIN-II RECEPTOR ANTAGONISTS

被引：25

作者：

ALLEN, EE ^{[1
]}

DELASZLO, SE ^{[1
]}

HUANG, SX ^{[1
]}

QUAGLIATO, CS ^{[1
]}

GREENLEE, WJ ^{[1
]}

CHANG, RSL ^{[1
]}

CHEN, TB ^{[1
]}

FAUST, KA ^{[1
]}

LOTTI, VJ ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,DEPT PHARMACOL,W POINT,PA 19486

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80334-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We present the design, syntheses, and in vitro biological data of a series of substituted quinazolinone containing, AT1 selective, Angiotensin II (AII) receptor antagonists. Substituents at the 6-position of the quinazolin-4(3H)-ones 3 have pronounced effects on the in vitro potency related to both their electronic and lipophilic character.

引用

页码：1293 / 1298

页数：6

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