INSULIN AND INSULIN-LIKE GROWTH-FACTOR-I STIMULATE EXPRESSION OF THE PRIMARY RESPONSE GENE CMG1/TIS11B BY A WORTMANNIN-SENSITIVE PATHWAY IN RIE-1 CELLS

被引：18

作者：

CORPS, AN ^{[1
]}

BROWN, KD ^{[1
]}

机构：

[1] AFRC,BABRAHAM INST,DEPT CELLULAR PHYSIOL,CAMBRIDGE CB2 4AT,ENGLAND

来源：

FEBS LETTERS | 1995年 / 368卷 / 01期

关键词：

INSULIN; PRIMARY RESPONSE GENE; PHOSPHATIDYLINOSITOL; 3-KINASE; MITOGEN-ACTIVATED PROTEIN KINASE; RIE-1 EPITHELIAL CELL;

D O I：

10.1016/0014-5793(95)00635-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of insulin or insulin-like growth factor I (TGF-I) to RIE-1 cells increased the expression of the primary response gene cMG1; dose-response analysis suggested that this effect was mediated largely through type 1 IGF receptors, Insulin/IGF-I did not affect the expression of the cMG1-related genes TIS11 and TIS11d, whereas epidermal growth factor, angiotensin II or 12-O-tetradecanoyl phorbol-13-acetate stimulated the expression of all three genes, Incubation with wortmannin (WM) prevented the insulin/IGF-I-induced elevation of cMG1 mRNA, but not that induced by the other mitogens or the stimulation of mitogen-activated protein kinase by insulin. We conclude that WM-sensitive phosphatidylinositol 3-kinase may be involved in the specific stimulation of cMG1 expression by insulin/IGF-I.

引用

页码：160 / 164

页数：5

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