IN-VIVO EFFECT OF CHLOROPHYLLIN ON GAMMA-RAY-INDUCED SISTER-CHROMATID EXCHANGE IN MURINE BONE-MARROW CELLS

The aim of the present work is to determine the radioprotective capacity of chlorophyllin, by measuring the reduction of gamma-ray-induced sister-chromatid exchange (SCE) in murine bone marrow cells in vivo. The results obtained in two separate experiments, using 10, 50 and 100 mu g of chlorophyllin per g of body weight (bw), indicate that chlorophyllin per se did not have any effect on the SCE frequency and that the dose of 100 mu g/g bw protects 100% against the induction of SCE by 1.0 Gy of gamma-rays; 50 mu g/g bw protects less than 50% and 10 mu g/g bw affords no protection.