BRADYKININ ANTAGONISTS - DEVELOPMENT AND APPLICATIONS

被引：85

作者：

STEWART, JM

机构：

[1] Department of Biochemistry, University of Colorado Medical School, Denver, Colorado

来源：

BIOPOLYMERS | 1995年 / 37卷 / 02期

关键词：

D O I：

10.1002/bip.360370208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bradykinin (BK) is involved in regulation of every major physiological system and is an initiator or mediator of many pathophysiological conditions. Rapid progress in understanding these aspects of BK biology has come since the discovery of BK antagonists. This article reviews principal points in the history of the kallikrein-kinin field and of kinin biology. The chemistry and development of antagonists for B1 and B2 kinin receptors is discussed. Uses of the antagonists in biomedical research and potential clinical applications are presented. (C) 1995 John Wiley & Sons, Inc.

引用

页码：143 / 155

页数：13

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