POLYMORPHISM OF SPIRONOLACTONE

被引：38

作者：

AGAFONOV, V

LEGENDRE, B

RODIER, N

WOUESSIDJEWE, D

CENSE, JM

机构：

[1] ECOLE NATL SUPER CHIM PARIS,INFORMAT CHIM LAB,F-75005 PARIS,FRANCE

[2] FAC PHARM CHATENAY MALABRY,PHARM GALEN & BIOPHARM LAB,CNRS,URA 1218,F-92296 CHATENAY MALABRY,FRANCE

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 02期

关键词：

D O I：

10.1002/jps.2600800221

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Single crystals of two polymorphic and four solvated crystalline forms of spironolactone (C24H32O4S) were obtained using different solvents. The morphology, symmetry, and crystallographic parameters were determined for all crystal forms except for the one obtained from methanol. The stability and transformation of each type of crystal were studied by DSC, TGA, and X-ray diffraction analysis. The structural data of three forms allowed the observation of the change of conformation of the molecules of spironolactone in the three different lattices.

引用

页码：181 / 185

页数：5

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