MULTIFACTORIAL ANALYSIS OF THE OUTCOME OF 6430 CADAVER KIDNEY GRAFTS

被引：11

作者：

BUSSON, M

PREVOST, P

BIGNON, JD

CAMBONTHOMSEN, A

OHAYON, E

GEBURHER, L

MERCIER, P

TONGIO, MM

RAFFOUX, C

HORS, J

机构：

[1] INSERM U93, Hôpital Saint-Louis, Paris Cedex 10, F-75475, 1, Avenue Claude Vellefaux

[2] France-Transplant, Hôpital Saint-Louis, Paris Cedex 10, F-75475, 1, Avenue Claude Vellefaux

来源：

TRANSPLANT INTERNATIONAL | 1992年 / 5卷 / 03期

关键词：

KIDNEY TRANSPLANTATION; RISK FACTORS; OUTCOME; RENAL GRAFTS; MULTIFACTORIAL ANALYSIS;

D O I：

10.1007/BF00336603

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A total of 6430 cadaver kidney grafts performed within the network of France-Transplant between 1 January 1978 and 1 January 1989 were analyzed. Each case was examined comprehensively in regard to 12 variables. A multifactorial analysis (Cox regression) was used to determine the degree of association between each co-variate and the outcome of the graft. The results were evaluated by calculating relative risks of graft failure for each variable. A total of seven covariates appeared to influence graft survival significantly: the period of transplantation (P = 10(-8)), retransplantations (P = 0.003), age and sex of the donor (P = 0.003 and 0.009 respectively), duration of pretransplant dialysis (P = 0.03), pretransplant sensitization to HLA antigens (P = 0.05), and matching for HLA-A, -B, and -DR loci (P = 0.03). This last parameter has previously been reported as influencing the outcome of the graft in seven out of eight international studies carried out using similar methodology.

引用

页码：162 / 164

页数：3

共 11 条

[1]

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[2]

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