THE RETINOBLASTOMA PROTEIN AND THE REGULATION OF CELL CYCLING

被引：173

作者：

COBRINIK, D

DOWDY, SF

HINDS, PW

MITTNACHT, S

WEINBERG, RA

机构：

[1] Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 08期

关键词：

D O I：

10.1016/0968-0004(92)90443-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing attention has been focused on how the retinoblastoma (RB) protein regulates cell growth. Recent evidence indicates that it is a substrate for phosphorylation by cyclin-dependent kinase-cyclin complexes and suggests that this phosphorylation modulates the ability of this protein to regulate transit through the cell cycle, perhaps in its G1 phase.

引用

页码：312 / 315

页数：4

共 40 条

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