RETROVIRUSES - DELIVERY VEHICLE TO THE LIVER

被引：21

作者：

GROSSMAN, M ^{[1
]}

WILSON, JM ^{[1
]}

机构：

[1] UNIV MICHIGAN, ANN ARBOR, MI 48109 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(05)80350-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Liver-directed gene therapy holds great promise for the treatment of inherited metabolic disease. Two strategies have emerged. Ex vivo gene therapy involves the transplantation of autologous hepatocytes transduced with recombinant retroviruses while in culture. The feasibility of this approach has been demonstrated in several animal models, and a human trial has been initiated. An alternative strategy uses recombinant viruses to deliver the transgene directly to hepatocytes in vivo.

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收藏

页码：110 / 114

页数：5

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