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MELT PELLETIZATION IN A HIGH-SHEAR MIXER .5. EFFECTS OF APPARATUS VARIABLES

被引：35
作者：
SCHAEFER, T
TAAGEGAARD, B
THOMSEN, LJ
KRISTENSEN, HG
机构：
[1] Royal Danish School of Pharmacy, Department of Pharmaceutics, Copenhagen
来源：
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 1993年 / 1卷 / 03期
关键词：
POLYETHYLENE GLYCOLS; PELLETS; MELT PELLETIZATION; MELT GRANULATION; HIGH SHEAR MIXER;
D O I：
10.1016/0928-0987(93)90003-S
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of two different sets of impeller blades on melt pelletization of lactose with polyethylene glycol (PEG) 3000 were investigated in an 8 litre high shear mixer. Results obtained in the 8 litre mixer were compared with previous results from a 50 litre high shear mixer of the same type. in the 8 litre mixer curved impeller blades were found to give rise to a high power input and smooth pellets of a spherical shape, whereas plane impeller blades caused a lower power input and irregular agglomerates. Agglomerate growth was found to be different in mixers of different scale. This difference was primarily ascribed to differences in movement of the mass, power input and product temperature.
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收藏
页码：133 / 141
页数：9
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