APOPTOSIS ASSOCIATED DNA FRAGMENTATION IN EPILEPTIC BRAIN-DAMAGE

被引：109

作者：

POLLARD, H

CANTAGREL, S

CHARRIAUTMARLANGUE, C

MOREAU, J

BENARI, Y

机构：

[1] INSERM U 29, Laboratoire de Neurobiologie et Physiopathologie du Développement, Hôpital de Port Royal, Paris, 75014

来源：

NEUROREPORT | 1994年 / 5卷 / 09期

关键词：

RAT HIPPOCAMPUS; EPILEPSY; KAINIC ACID; DNA FRAGMENTATION; APOPTOSIS;

D O I：

10.1097/00001756-199405000-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE have examined the epileptic brain damage generated by intra-amygdaloid administration of kainic acid (KA). In the vulnerable CA3 region of the rat hippocampus, neurones developed apoptotic properties since, (i) their nuclei were positively stained with a selective in situ DNA fragmentation staining method; (ii) DNA cleavage into internucleosome-sized fragments was observed on agarose gels. Our results suggest that epileptic seizures generated in the amygdala by KA trigger apoptotic cell damage in pyramidal CA3 neurones.

引用

页码：1053 / 1055

页数：3

共 19 条

[1] LIMBIC SEIZURE AND BRAIN-DAMAGE PRODUCED BY KAINIC ACID - MECHANISMS AND RELEVANCE TO HUMAN TEMPORAL-LOBE EPILEPSY [J].

BENARI, Y .

NEUROSCIENCE, 1985, 14 (02) :375-403

[2] INJECTIONS OF KAINIC ACID INTO THE AMYGDALOID COMPLEX OF THE RAT - AN ELECTROGRAPHIC, CLINICAL AND HISTOLOGICAL STUDY IN RELATION TO THE PATHOLOGY OF EPILEPSY [J].

BENARI, Y ;

TREMBLAY, E ;

OTTERSEN, OP .

NEUROSCIENCE, 1980, 5 (03) :515-528

[3] EVIDENCE SUGGESTING SECONDARY EPILEPTOGENIC LESIONS AFTER KAINIC ACID - PRETREATMENT WITH DIAZEPAM REDUCES DISTANT BUT NOT LOCAL BRAIN-DAMAGE [J].

BENARI, Y ;

TREMBLAY, E ;

OTTERSEN, OP ;

NAQUET, R .

BRAIN RESEARCH, 1979, 165 (02) :362-365

[4]

BROWN DG, 1993, J BIOL CHEM, V268, P3037

[5] THE BIOCHEMISTRY OF CELL-DEATH BY APOPTOSIS [J].

BURSCH, W ;

KLEINE, L ;

TENNISWOOD, M .

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1990, 68 (09) :1071-1074

[6] INSITU INJECTION OF KAINIC ACID - NEW METHOD FOR SELECTIVELY LESIONING NEURONAL CELL BODIES WHILE SPARING AXONS OF PASSAGE [J].

COYLE, JT ;

MOLLIVER, ME ;

KUHAR, MJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 180 (02) :301-323

[7]

DUHEN LW, 1992, GREENFIELDS NEUROPAT, P11

[8] IDENTIFICATION OF PROGRAMMED CELL-DEATH INSITU VIA SPECIFIC LABELING OF NUCLEAR-DNA FRAGMENTATION [J].

GAVRIELI, Y ;

SHERMAN, Y ;

BENSASSON, SA .

JOURNAL OF CELL BIOLOGY, 1992, 119 (03) :493-501

[9] DETECTION OF DNA FRAGMENTATION IN APOPTOSIS - APPLICATION OF INSITU NICK TRANSLATION TO CELL-CULTURE SYSTEMS AND TISSUE-SECTIONS [J].

GOLD, R ;

SCHMIED, M ;

ROTHE, G ;

ZISCHLER, H ;

BREITSCHOPF, H ;

WEKERLE, H ;

LASSMANN, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1993, 41 (07) :1023-1030

[10]

Kerr J.F.R., 1987, P93

← 1 2 →