ISOTYPE AND ANTIGEN-SPECIFICITY OF PERTUSSIS AGGLUTININS FOLLOWING WHOLE-CELL PERTUSSIS VACCINATION AND INFECTION WITH BORDETELLA-PERTUSSIS

被引：25

作者：

MINK, CM

OBRIEN, CH

WASSILAK, S

DEFOREST, A

MEADE, BD

机构：

[1] CTR DIS CONTROL & PREVENT, DIV IMMUNIZAT, ATLANTA, GA USA

[2] TEMPLE UNIV, ST CHRISTOPHERS HOSP CHILDREN, SCH MED, DEPT PEDIAT, PHILADELPHIA, PA USA

[3] US FDA, CTR BIOL EVALUAT & RES, DIV BACTERIAL PROD, PERTUSSIS LAB, BETHESDA, MD 20892 USA

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 03期

关键词：

D O I：

10.1128/IAI.62.3.1118-1120.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elevated agglutinin titers have been shown to correlate with protection from disease following whole-cell pertussis vaccination, but the isotype and antigen specificity of human agglutinating antibodies is unknown. In 13 immunoassays, immunoglobulin G antifimbria antibodies had the strangest correlation with agglutinin titers following culture-proven infection with Bordetella pertussis (R' = 0.79; P < 0.0001) and following whole-cell pertussis vaccination (R' = 0.87, P < 0.0001).

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页码：1118 / 1120

页数：3

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