LOCALIZATION OF X-CHROMOSOME SHORT ARM MARKERS RELATIVE TO SYNOVIAL SARCOMA-ASSOCIATED AND RENAL ADENOCARCINOMA-ASSOCIATED TRANSLOCATION BREAKPOINTS

被引：16

作者：

SINKE, RJ

DELEEUW, B

JANSSEN, HAP

WEGHUIS, DO

SUIJKERBUIJK, RF

MELONI, AM

GILGENKRANTZ, S

BERGER, W

ROPERS, HH

SANDBERG, AA

VANKESSEL, AG

机构：

[1] GENET CTR,SCOTTSDALE,AZ

[2] CANC CTR,SCOTTSDALE,AZ

[3] CTR REG TRANSFUS SANGUINE,GENET LAB,NANCY,FRANCE

来源：

HUMAN GENETICS | 1993年 / 92卷 / 03期

关键词：

D O I：

10.1007/BF00244478

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.

引用

页码：305 / 308

页数：4

共 21 条

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