CARDIOMYOPATHY - A ROLE FOR NITRIC-OXIDE

被引：12

作者：

DEBELDER, A ^{[1
]}

MONCADA, S ^{[1
]}

机构：

[1] WELLCOME RES FDN LTD,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 1995年 / 50卷 / 03期

关键词：

CARDIOMYOPATHY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

D O I：

10.1016/0167-5273(95)02386-B

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The negative inotropism, myocardial dilatation and cytotoxicity in inflammatory heart disorders may be due to increased generation of nitric oxide (NO) by immunological induction of a high output NO pathway. This short review discusses the initial experiments which lead to this hypothesis, and evaluates data that this pathway exists in animal and human cardiomyopathic disorders. It is proposed that manipulation of this pathway may prove to be beneficial in patients with these disorders.

引用

收藏

页码：263 / 268

页数：6

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