DIMINUTION OF L-CELL MICROVILLI FOLLOWING EXPOSURE TO 25-HYDROXYCHOLESTEROL

被引：9

作者：

LIN, PS ^{[1
]}

CHEN, HW ^{[1
]}

机构：

[1] JACKSON LAB,BAR HARBOR,ME 04609

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1979年 / 3卷 / 01期

关键词：

D O I：

10.1016/0309-1651(79)90068-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effect of sterol depletion on the topology of mouse L cells was studied by scanning electron microscopy. Treatment of cells with 25-hydroxycholesterol inhibited the synthesis of cellular sterol and diminished the number of microvilli on the cell surface. Simultaneous addition of mevalonic acid or cholesterol to cells during treatment with the inhibitor prevented the loss of microvilli. These results demonstrate that cholesterol is important in maintaining the ultrastructure of the surface membrane of nucleated mammalian cells. © 1979.

引用

页码：51 / 59

页数：9

共 28 条

[1]

ASWAD C, 1976, P SOC EXP BIOL MED, V153, P505, DOI 10.3181/00379727-153-39579

[2]

Chen H W, 1978, Prog Exp Tumor Res, V22, P275

[3] RELATIONSHIP BETWEEN STEROL SYNTHESIS AND DNA-SYNTHESIS IN PHYTOHEMAGGLUTININ-STIMULATED MOUSE LYMPHOCYTES [J].