DNA BENDING INDUCED BY COVALENTLY BOUND DRUGS - GEL-ELECTROPHORESIS AND CHEMICAL PROBE STUDIES

被引：29

作者：

LENG, M

机构：

[1] Centre de Biophysique Moléculaire, 1A, Avenue de la Recherche Scientifique

来源：

BIOPHYSICAL CHEMISTRY | 1990年 / 35卷 / 2-3期

关键词：

Chemical probe; DNA bending; Gel electrophoresis; Modified nucleotide residue;

D O I：

10.1016/0301-4622(90)80005-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modification of nucleotide residues arising from the covalent binding of a drug or as a result of irradiation with ultraviolet light can induce distortion of the DNA double helix. The purpose of this review is to show that, from investigation of the electrophoretic mobility of the modified DNA fragments, one can deduce whether the distortions behave more as the centers of directed bends or as hinge joints. It is also demonstrated that chemical probes are a complementary tool for the analysis of distortions at the nucleotide level. © 1990.

引用

页码：155 / 163

页数：9

共 86 条

[1]

BELAND F, 1982, CANCER RES, V42, P2348

[2] THE INTRINSIC CURVATURE OF DNA IN SOLUTION [J].