STEREOCONTROLLED ADDITION OF PROPIONATE HOMOENOLATE EQUIVALENTS TO CHIRAL ALPHA-AMINO ALDEHYDES

被引：73

作者：

DECAMP, AE

KAWAGUCHI, AT

VOLANTE, RP

SHINKAI, I

机构：

[1] Department of Process Research Merck, Sharp and Dohme Research Laboratories, Rahway, NJ 07065-0900

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(00)85983-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient route is presented for preparation of the medicinally important hydroxyester and lactone intermediates 1 and 2 from chiral alpha-amino aldehydes via homoenolate methodology. Several reaction variables were found to influence the ratio of chelation controlled versus Felkin-Ahn products.

引用

页码：1867 / 1870

页数：4

共 33 条

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