EFFECT OF PONSINOMYCIN ON CYCLOSPORINE PHARMACOKINETICS

被引：12

作者：

COUET, W ^{[1
]}

ISTIN, B ^{[1
]}

SENIUTA, P ^{[1
]}

MOREL, D ^{[1
]}

POTAUX, L ^{[1
]}

FOURTILLAN, JB ^{[1
]}

机构：

[1] HOP PELLEGRIN TRIPODE,SERV NEPHROL,BORDEAUX,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 02期

关键词：

Cyclosporin A; drug interaction; macrolide antibiotic; pharmacokinetics; ponsinomycin; renal transplantation;

D O I：

10.1007/BF00280052

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of treatment with ponsinomycin, a new macrolide antibiotic, on the pharmacokinetics of cyclosporin A has been studied in 10 renal transplant patients. The pharmacokinetics of cyclosporin A was investigated at steady state, before and during treatment with ponsinomycin. On average, the blood levels of cyclosporin A were doubled by the macrolide, possibly due to a decrease in elimination or/and to an increase in absorption. Ponsinomycin should be use very carefully in patients treated with cyclosporin A. © 1990 Springer-Verlag.

引用

页码：165 / 167

页数：3

共 24 条

[1] CYCLOSPORINE PHARMACOKINETIC DRUG-INTERACTIONS [J].