MODEL OF HIGH-AFFINITY GLUTAMIC-ACID TRANSPORT BY RAT CORTICAL SYNAPTOSOMES - REFINEMENT OF THE ORIGINALLY PROPOSED MODEL

Abstract– In a previous publication (Wheeler & Hollingsworth, 1978), a model was presented which accounted for the role of sodium in the high affinity transport of glutamic acid in rat brain synaptosomes. Subsequent studies confirmed a lack of fit of the model to the data at the higher sodium and glutamate concentrations. The model has therefore been reexamined and refined. By removing some of the restrictions placed on the original model, a model emerges which fits the data at all sodium and glutamate concentrations with an average per cent error of only 2.14% per experimental data point. The kinetic constants describing uptake have been redefined and recalculated in accordance with this revised model. Copyright © 1979, Wiley Blackwell. All rights reserved