INFLUENCE OP REMOTE STRUCTURE UPON REGIOSELECTIVITY IN THE N-ALKYLATION OF 2-AMINO-6-CHLOROPURINE - APPLICATION TO THE SYNTHESIS OF PENCICLOVIR

被引：8

作者：

CHOUDARY, BM ^{[1
]}

GEEN, GR ^{[1
]}

GRINTER, TJ ^{[1
]}

MACBEATH, FS ^{[1
]}

PARRATT, MJ ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 04期

关键词：

D O I：

10.1080/15257779408011871

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of 2-amino-6-chloropurine with trans-2-alkyl-5-iodoethyl-1,3-dioxanes under basic conditions afforded N-9 and N-7 alkylated products, the product ratio obtained being dependent on the size of the 2-alkyl group. This allowed a highly regioselective key step in the synthesis of the anti-herpes agent penciclovir.

引用

页码：979 / 996

页数：18

共 20 条

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