EFFECT OF NEOPTERIN AND 7,8-DIHYDRONEOPTERIN ON TUMOR-NECROSIS-FACTOR-ALPHA INDUCED PROGRAMMED CELL-DEATH

被引：73

作者：

BAIERBITTERLICH, G

FUCHS, D

MURR, C

REIBNEGGER, G

WERNERFELMAYER, G

SGONC, R

BOCK, G

DIERICH, MP

WACHTER, H

机构：

[1] UNIV INNSBRUCK, INST EXPTL PATHOL, A-6020 INNSBRUCK, AUSTRIA

[2] UNIV INNSBRUCK, INST HYG, A-6020 INNSBRUCK, AUSTRIA

来源：

FEBS LETTERS | 1995年 / 364卷 / 02期

关键词：

PTERIDINE; APOPTOSIS; REACTIVE OXYGEN INTERMEDIATE; NEOPTERIN; 7,8-DIHYDRONEOPTERIN; HUMAN MONOCYTE;

D O I：

10.1016/0014-5793(95)00403-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor necrosis factor-alpha and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data indicated a role of neopterin and 7,8-dihydroneopterin in oxygen radical mediated processes. We have therefore investigated the effect of neopterin-derivatives on TNF alpha induced apoptosis of the monocyte-like cell line U937. At an elevated concentration 7,8-dihydroneopterin was found to superinduce TNF alpha mediated programmed cell death due to the formation of reactive oxygen intermediates. Our results imply that in combination with TNF alpha high concentrations of 7,8-dihydroneopterin enhances apoptosis due to oxidative stress on cells.

引用

页码：234 / 238

页数：5

共 35 条

[1] CHARACTERIZATION OF RECEPTORS FOR HUMAN-TUMOR NECROSIS FACTOR AND THEIR REGULATION BY GAMMA-INTERFERON [J].