EFFECTS OF VARYING BORON-10 DOSE THERMAL NEUTRON FLUENCE AND REACTOR EMPLOYED ON RESULTS OF NEUTRON CAPTURE THERAPY OF A TRANSPLANTABLE MOUSE NEOPLASM

Data are presented comparing results from neutron capture therapy of a transplantable mouse neoplasm after doses of boron-10 equivalent to 25, 35 and 50 micrograms per gram body weight at comparable thermal neutron fluences; also data are presented comparing results with three differently designed nuclear reactors. In addition, in two of the studies to provide an extension of control data, data are presented of results obtained at very low thermal neutron fluences. Comments and data cover borate distribution among blood, neoplasm and muscle with a discernably different pattern emerging at the higher boron dose compared to the lower. The data reported are on 627 animals bearing neoplasms. From 50 to 79 per cent of treated animals, depending upon the specific study, showed complete and permanent (lifetime) regression of the neoplasm. © 1968.