THE NEUROPEPTIDE PHE-MET-ARG-PHE-NH2 (FMRFAMIDE) CAN ACTIVATE A LIGAND-GATED ION CHANNEL IN HELIX NEURONS

被引：68

作者：

COTTRELL, GA ^{[1
]}

GREEN, KA ^{[1
]}

DAVIES, NW ^{[1
]}

机构：

[1] UNIV LEICESTER,DEPT PHYSIOL,LEICESTER LE1 9HN,ENGLAND

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1990年 / 416卷 / 05期

关键词：

depolarisation; FMRFamide; Na[!sup]+[!/sup] ions; single-channel;

D O I：

10.1007/BF00382698

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

This report presents evidence that the molluscan neuropeptide FMRFamide can directly activate a ligand-gated ion channel in Helix neurones. Using the patch-clamp technique we have observed unitary currents activated by the application of FMRFamide onto outside-out patches. As for the whole-cell response, Na+ ions are the main charge carriers. We conclude that FMRFamide may act as a fast depolarising neurotransmitter in the Helix nervous system. © 1990 Springer-Verlag.

引用

页码：612 / 614

页数：3

共 10 条

[1] GUANOSINE 5'-TRIPHOSPHATE ANALOG ACTIVATES POTASSIUM CURRENT MODULATED BY NEUROTRANSMITTERS IN APLYSIA NEURONS [J].

BREZINA, V .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 407 :15-40

[2] EFFECT OF CURARE ON RESPONSES TO DIFFERENT PUTATIVE NEUROTRANSMITTERS IN APLYSIA NEURONS [J].

CARPENTER, DO ;

SWANN, JW ;

YAROWSKY, PJ .

JOURNAL OF NEUROBIOLOGY, 1977, 8 (02) :119-132

[3]

Cottrell G.A., 1983, P213

[4] MULTIPLE ACTIONS OF A MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE AND RELATED PEPTIDES ON IDENTIFIED HELIX NEURONS [J].

COTTRELL, GA ;

DAVIES, NW ;

GREEN, KA .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 356 (NOV) :315-333

[5] 5-HT3 RECEPTORS ARE MEMBRANE ION CHANNELS [J].

DERKACH, V ;

SURPRENANT, A ;

NORTH, RA .

NATURE, 1989, 339 (6227) :706-709

[6] NICOTINIC-TYPE UNITARY CURRENTS IN HELIX NEURONS [J].

GREEN, KA ;

CADOGAN, A ;

COTTRELL, GA .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY, 1989, 93 (01) :47-51

[7]

GREEN KA, 1990, J EXP BIOL, V149, P79

[8] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES [J].

HAMILL, OP ;

MARTY, A ;

NEHER, E ;

SAKMANN, B ;

SIGWORTH, FJ .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02) :85-100

[9] A HISTAMINE-ACTIVATED CHLORIDE CHANNEL INVOLVED IN NEUROTRANSMISSION AT A PHOTORECEPTOR SYNAPSE [J].

HARDIE, RC .

NATURE, 1989, 339 (6227) :704-706

[10]

RUBEN P, 1986, J NEUROSCI, V6, P252

← 1 →