The utility of (99m)Tc-IDA imaging in the differential diagnosis of jaundice was assessed. Although overall accuracy was 84%, this method is still inferior to the reported efficiency of ultrasonography and CT in making the correct diagnosis. Radionuclide imaging is a good alternative when these other modalities are not available and it functions well in an adjuvant capacity. The diagnostic limitations of (99m)Tc-dimethyl IDA imaging in cases of moderate to severe jaundice are largely overcome by the use of (99m)Tc-p-butyl IDA.