FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY AND COLLISIONAL SPECTROSCOPY IN THE STRUCTURAL CHARACTERIZATION OF UNDERIVATIZED 1,4-BENZODIAZEPINES

被引：6

作者：

GHEZZO, E ^{[1
]}

TRALDI, P ^{[1
]}

MINGHETTI, G ^{[1
]}

CINELLU, MA ^{[1
]}

BANDINI, AL ^{[1
]}

BANDITELLI, G ^{[1
]}

ZECCA, L ^{[1
]}

机构：

[1] CNR,AREA RIC,CORSO STATI UNITI 4,I-35100 PADUA,ITALY

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1990年 / 4卷 / 09期

关键词：

D O I：

10.1002/rcm.1290040904

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Fast‐atom bombardment (FAB) mass spectrometry linked with collision spectroscopy has been employed for the structural characterization of eight underivatized 1,4‐benzodiazepines. Both positive‐ and negative‐ion FAB led, in all cases examined, to the production of abundant molecular species. Collision experiments performed on such ions gave rise to the identification of diagnostic fragment ions, that could be related to the original structure. Copyright © 1990 John Wiley & Sons Limited

引用

页码：314 / 317

页数：4

共 15 条

[1]

Goodman and Gilman's The Pharmacological Basis of Therapeutics, (1985)

[2]

Schutz H., Benzodiazepines II, (1989)

[3]

Sternbach L.H., Angew, Chem. Int. Ed. Engl., 10, (1971)

[4]

Sternbach L.H., J. Med. Chem., 22, (1979)

[5]

Allgulander C., Acta Psychiatr. Scand., 270, (1978)

[6]

Kales A., Bixler E.O., Kales J.D., Scharf M.B., J. Clin. Pharmacol., 17, (1977)

[7]

Scaplehorn A., (1986)

[8]

Joyce J.R., Bal T.S., Ardrey R.E., Stevens H.M., Moffat A.C., Biomed. Environ. Mass Spectrom., 11, (1984)

[9]

de Silva J.A.F., Bekersky I., Puglisi C.V., Brooks M.A., Weinfeld R.E., Anal. Chem., 48, (1976)

[10]

Sadee W., J. Med. Chem., 13, (1970)

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