MECHANISM OF CONVERSION OF DETHIOBIOTIN TO BIOTIN IN ESCHERICHIA-COLI - DISCUSSION OF THE OCCURRENCE OF AN INTERMEDIATE HYDROXYLATION

被引：28

作者：

FRAPPIER, F ^{[1
]}

GUILLERM, G ^{[1
]}

SALIB, AG ^{[1
]}

MARQUET, A ^{[1
]}

机构：

[1] CNRS, CERCOA, 2-8 RUE HENRY DUNANT, F-94320 THIAIS, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91553-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The last step of the biosynthesis of biotin, i.e., the conversion of dethiobiotin to biotin was studied using E. coli. The 3 dethiobiotin derivatives hydroxylated at C-2 or C-5 were synthesized and tested as potential precursors of biotin. None of these compounds is able to support the growth of E. coli C124, a mutant which does not synthesize dethiobiotin, but converts it into biotin. The hypothesis of the activation of the saturated C by a hydroxylation process was not supported.

引用

页码：521 / 527

页数：7

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