ISOLATION OF THE OPIOID HEPTAPEPTIDE MET-ENKEPHALIN [ARG6,PHE7] FROM BOVINE ADRENAL-MEDULLARY GRANULES AND STRIATUM

被引：281

作者：

STERN, AS

LEWIS, RV

KIMURA, S

ROSSIER, J

GERBER, LD

BRINK, L

STEIN, S

UDENFRIEND, S

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 12期

关键词：

D O I：

10.1073/pnas.76.12.6680

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bovine adrenal chromaffin granules have been shown to contain, in addition to Met-enkephalin and Leu-enkephalin, at least three small peptides with opiate receptor activity. One of these adrenal peptides has been purified to homogeneity and its sequence was shown to be Met-enkephalin-[Arg 6,Phe 7]. This heptapeptide was also found in beef striatal extracts in amounts comparable to those of Leu-enkephalin.

引用

页码：6680 / 6683

页数：4

共 19 条

[1] AUTOMATIC MONITORING OF PRIMARY AMINES IN PREPARATIVE COLUMN EFFLUENTS WITH FLUORESCAMINE
BOHLEN, P
STEIN, S
STONE, J
UDENFRIEND, S
[J]. ANALYTICAL BIOCHEMISTRY, 1975, 67 (02) : 438 - 445
[2] COSTA E, 1979, FED PROC, V38, P1129
[3] GERBER L D, 1978, Brain Research, V151, P117
[4] Gray W R, 1972, Methods Enzymol, V25, P333, DOI 10.1016/S0076-6879(72)25029-7
[5] RADIOIMMUNOASSAY OF METHIONINE-ENKEPHALINS AND LEUCINE-ENKEPHALINS IN REGIONS OF RAT-BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY
GROS, C
PRADELLES, P
ROUGET, C
BEPOLDIN, O
DRAY, F
FOURNIEZALUSKI, MC
ROQUES, BP
POLLARD, H
LLORENSCORTES, C
SCHWARTZ, JC
[J]. JOURNAL OF NEUROCHEMISTRY, 1978, 31 (01) : 29 - 39
[6] IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY
HUGHES, J
SMITH, TW
KOSTERLITZ, HW
FOTHERGILL, LA
MORGAN, BA
MORRIS, HR
[J]. NATURE, 1975, 258 (5536) : 577 - 579
[7] ALPHA-NEO-ENDORPHIN - BIG LEU-ENKEPHALIN WITH POTENT OPIATE ACTIVITY FROM PORCINE HYPOTHALAMI
KANGAWA, K
MATSUO, H
IGARASHI, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 86 (01) : 153 - 160
[8] HIGH MOLECULAR-WEIGHT OPIOID-CONTAINING PROTEINS IN STRIATUM
LEWIS, RV
STEIN, S
GERBER, LD
RUBINSTEIN, M
UDENFRIEND, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) : 4021 - 4023
[9] PUTATIVE ENKEPHALIN PRECURSORS IN BOVINE ADRENAL-MEDULLA
LEWIS, RV
STERN, AS
ROSSIER, J
STEIN, S
UDENFRIEND, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 89 (03) : 822 - 829
[10] LEWIS RV, 1979, ADV BIOCH PSYCHOPHAR, V20

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