A SINGLE NEOPLASTIC CLONE IN SEQUENTIAL BIOPSY SPECIMENS FROM A PATIENT WITH PRIMARY GASTRIC-MUCOSA-ASSOCIATED LYMPHOID-TISSUE LYMPHOMA AND SJOGRENS-SYNDROME

Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) that occur in the stomach, small intestine, salivary gland, lung, and thyroid are indolent neoplasms characterized by a prolonged clinical course and persistent disease at the site of origin1. The mechanism by which the neoplastic cells remain committed to a single site, the presence or absence of neoplastic-cell traffic or homing, and the specific dissemination of MALT lymphomas to other mucosal sites2 are all properties of these lymphomas that are poorly understood. Investigation of these features has been hampered by the absence of a tumor-cell-specific marker with which to examine the… © 1993, Massachusetts Medical Society. All rights reserved.