EFFECT OF ADJUVANT THERAPY ON DEVELOPMENT OF DIABETES IN MOUSE AND MAN

被引：145

作者：

SHEHADEH, N

CALCINARO, F

BRADLEY, BJ

BRUCHLIM, I

VARDI, P

LAFFERTY, KJ

机构：

[1] RAMBAM MED CTR,JUVENLLE DIABET CTR,HAIFA,ISRAEL

[2] BARBARA DAVIS CTR CHILDHOOD DIABET,DENVER,CO

来源：

LANCET | 1994年 / 343卷 / 8899期

关键词：

D O I：

10.1016/S0140-6736(94)91583-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Freund's complete adjuvant (CFA) and BCG vaccine modulate the development of type 1 diabetes in animal models. In non-obese diabetic mice, CFA and BCG significantly reduced the proportion developing diabetes compared with controls. Histological examination showed that autoimmune disease still developed but had been diverted to become nondestructive. In a preliminary trial in 17 newly diagnosed, type 1 diabetic patients, intracutaneous administration of 0.1 mL of BCG 1 mg/mL led to clinical remission in 11 (65%)-by week 4 in 6. Remission has been sustained in 3 for 6-10 months. No side-effects were reported. A double-blind trial of BCG is warranted.

引用

页码：706 / 707

页数：2

共 6 条

[1]

GUYTINGCO R, 1991, DIABETES, V40, pA152

[2]

LAKEY JRT, 1992, TRANSPLANT P, V24, P2848

[3] PREVENTION OF INSULITIS AND DIABETES ONSET BY TREATMENT WITH COMPLETE FREUND ADJUVANT IN NOD MICE [J].