C-TERMINAL AMINO-GROUPS FACILITATE MEMBRANE INCORPORATION OF GRAMICIDIN DERIVATIVES

被引：11

作者：

JAIKARAN, DCJ ^{[1
]}

ZHANG, ZH ^{[1
]}

WOOLLEY, GA ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT CHEM,TORONTO,ON M5S 1A1,CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1995年 / 1234卷 / 01期

关键词：

GRAMICIDIN; PEPTIDE; LIPID; MEMBRANE; PROTEIN FOLDING;

D O I：

10.1016/0005-2736(94)00307-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gramicidin derivatives with (positively-charged) C-terminal amino groups are found to incorporate readily and refold quickly when added to dioleoylphosphatidylcholine lipid vesicles from concentrated methanol solutions. Neutral and negatively-charged derivatives do not.

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页码：133 / 138

页数：6

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