ERYTHROMYCIN STEARATE IN ACNE-VULGARIS - ITS EFFECT ON SKIN SURFACE-LIPIDS AND ON ACTIVITY OF PURIFIED PANCREATIC LIPASE

被引：8

作者：

HELLGREN, L ^{[1
]}

VINCENT, J ^{[1
]}

机构：

[1] UNIV GOTHENBURG,FAC MED,DEPT STRUCT CHEM,S-40033 GOTHENBURG 33,SWEDEN

来源：

DERMATOLOGICA | 1978年 / 156卷 / 02期

关键词：

Acne vulgaris; Erythromycin stearate; Pancreatic lipase; Skin surface lipids;

D O I：

10.1159/000250905

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

To study the mechanism of action of erythromycin stearate in acne vulgaris, the composition of the skin surface lipids was analyzed before, during and after treatment (500 mg daily for 1 week, 250 mg daily for 2 months) in 17 patients. Quantitative thin-layer chromatography showed that the fatty acid fraction in the skin surface lipids decreased significantly during the treatment period. The clinical effect was good in 14 of 17 patients. Further investigations were performed on the effect of erythromycin stearate on purified pancreatic lipase. The enzyme activity was not inhibited by exposure to the drug. © 1978 S. Karger AG, Basel.

引用

页码：105 / 110

页数：6

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