LOSS OF AUTOREGULATION AND POST-TRAUMATIC ISCHEMIA FOLLOWING EXPERIMENTAL SPINAL-CORD TRAUMA

被引:109
作者
SENTER, HJ
VENES, JL
机构
关键词
D O I
10.3171/jns.1979.50.2.0198
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Blood flow in the dorsolateral funiculus of the cat thoracic spinal cord was studied after severe experimental cord injury, using a modification of the hydrogen clearance technique. Autoregulation was intact during the initial 60 to 90 minutes after cord injury, but was then lost coincident with the onset of ischemia. The data suggest that the ischemic response to spinal cord injury is mediated both by the loss of autoregulation and by relative vasoconstriction of the resistance vessels. Therapeutic intervention aimed at maintaining perfusion during the early posttraumatic period may prove of value in reversing or limiting some elements of dysfunction due to the secondary injury of ischemia.
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页码:198 / 206
页数:9
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