DETERMINATION OF THE STABILITY OF MITOMYCIN-C BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：24

作者：

EDWARDS, D

SELKIRK, AB

TAYLOR, RB

机构：

[1] School of Pharmacy, Robert Gordon 's Institute of Technology, Aberdeen, AB9 1FR Scotland, Schoolhill

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 4卷 / 01期

关键词：

D O I：

10.1016/0378-5173(79)90094-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stability of mitomycin C in normal saline solution at elevated temperatures has been investigated by an high-performance liquid chromatography method. The reaction is found to follow first order kinetics and the rate constant for the decomposition at 25°C is estimated by extrapolation. The decomposition of mitomycin C is shown to produce different products in acid and basic solutions by utilising the technique of soap chromatography. First order rate constants are reported as a function of pH and the advantages of the high-performance liquid chromatography method when applied to such rate studies are discussed. © 1979.

引用

页码：21 / 26

页数：6

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