GENETIC AND ENVIRONMENTAL-INFLUENCES ON ECHOCARDIOGRAPHICALLY DETERMINED LEFT-VENTRICULAR MASS IN BLACK TWINS

被引：82

作者：

HARSHFIELD, GA

GRIM, CE

HWANG, C

SAVAGE, DD

ANDERSON, SJ

机构：

[1] The Department of Medicine, The Charles R. Drew University of Medicine and Science, Los Angeles, CA

[2] Uniformed Services University of the Health Sciences, Bethesda, Maryland, and Morehouse School of Medicine, Atlanta, GA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 07期

关键词：

Blacks; Deoxycorticosterone; Gene-environment interaction; Left ventricular hypertrophy; Left ventricular mass;

D O I：

10.1093/ajh/3.7.538

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Genetic and environmental influences on left ventricular mass were examined in normotensive black twins. Left ventricular mass was measured echocardiographically in 7 sets of monozygotic (MZ) and 15 sets of dizygotic (DZ) twins and adjusted for body surface area (LVMI). Regression analyses showed significant effects of gender (R2 = 0.48; P <.01), systolic blood pressure (R2= 0.21; P <.01) and age (R2= 0.10; P <.05) on LVMI but did not show an effect for either diastolic blood pressure or caloric expenditure. Monozygotic twins showed smaller within-pair differences (7 ± 5) than DZ twins (17 ± 11) for LVMI following adjustment for gender, systolic blood pressure and age (P <.03). The intraclass correlation for MZ twins was 0.90 (P <.01) and 0.33 (P = NS) for DZ twins. These results indicate that both genetic and environmental factors are important determinants of left ventricular mass in blacks, independent of gender, blood pressure and age. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：538 / 543

页数：6

共 23 条

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