REVERSAL OF DAUNORUBICIN RESISTANCE IN P388/ADR CELLS BY ITRACONAZOLE

被引：50

作者：

GUPTA, S

KIM, JM

GOLLAPUDI, S

机构：

[1] Div. of Basic and Clin. Immunology, University of California, Irvine

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1991年 / 87卷 / 04期

关键词：

P-GLYCOPROTEIN; MULTIDRUG RESISTANCE; PLASMA MEMBRANE POTENTIAL; DRUG ACCUMULATION; TRIAZOLES;

D O I：

10.1172/JCI115154

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Itraconazole is a recently developed triazole antifungal agent that inhibits cell membrane sterol biosynthesis. Itraconazole, in a dose-dependent manner, enhanced intracellular accumulation of daunorubicin and reversed the drug resistance in murine leukemia P388/ADR cells. In addition, itraconazole corrected the altered plasma membrane potentials of P388/ADR cells. The concentrations of itraconazole that reversed drug resistance are comparable to the plasma levels achieved by therapeutic dosage used in the treatment of fungal infections. Therefore, itraconazole is a potential candidate for in vivo use to reverse multidrug resistance in cancer with added benefit of its antifungal property.

引用

页码：1467 / 1469

页数：3

共 18 条

[1]

Berg D, 1988, Ann N Y Acad Sci, V544, P338, DOI 10.1111/j.1749-6632.1988.tb40418.x

[2] MECHANISM OF MULTIDRUG RESISTANCE [J].