PREPARATION OF ACYCLIC N-ACYL-N,O-ACETALS BY DECARBOXYLATION OF N-PROTECTED ALPHA-AMINO-ACIDS AND STUDIES OF ASYMMETRIC AMIDOALKYLATION WITH TRIMETHYLSILYL CYANIDE

被引：9

作者：

HARDING, KE

LIU, LT

FARRAR, DG

COLEMAN, MT

TANSEY, SK

机构：

[1] Department of Chemistry, Texas A&M University, TX 77843, College Station

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 12-13期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/00397919108021290

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidative decarboxylation of N-acyl-alpha-amino acids with lead tetra-acetate followed by treatment with methanol provides a facile method for preparation of acyclic N-acyl-N,O-acetals, which can be used in asymmetric alpha-amidoalkylation reactions using trimethylsilyl cyanide as nucleophile.

引用

收藏

页码：1409 / 1417

页数：9

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