BIOLOGICAL ACTIONS OF ATRIAL-NATRIURETIC-FACTOR IN FLATFISH

被引:12
作者
ARNOLDREED, D
HAZON, N
BALMENT, RJ
机构
[1] UNIV ST ANDREWS,GATTY MARINE LAB,DEPT BIOL & PRECLIN MED,ST ANDREWS KY16 8LB,SCOTLAND
[2] UNIV MANCHESTER,SCH BIOL SCI,DEPT PHYSIOL SCI,MANCHESTER M13 9PT,LANCS,ENGLAND
关键词
ATRIAL NATRIURETIC FACTOR (ANF); CORTISOL; SODIUM; BLOOD PRESSURE; TELEOST FISH;
D O I
10.1007/BF02265148
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Flounder adapted to seawater were chronically cannulated and received a single i.v. injection of either saline (control) or 10-mu-g/kg b.w. of human ANF. Compared to controls, ANF significantly reduced (p < 0.001) mean arterial blood pressure; full recovery was evident after 4 hours. Blood samples taken at intervals after saline or ANF injection showed that ANF caused a marked increase of 33.7-mu-g/100 ml in plasma cortisol concentration (p < 0.001) 5 hours post injection. The rate of recovery of Na-22 in seawater after a single i.v. injection of 14 x 10(6) cpm/kg Na-22Cl was significantly increased (p < 0.01) following ANF injection compared to controls suggesting that ANF stimulates Na+ efflux. This observation was confirmed in plaice and dab. The steroidogenic action of ANF and its ability to promote Na+ efflux are discussed in relation to its potential osmoregulatory role in teleost fish.
引用
收藏
页码:271 / 277
页数:7
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