THE CLINICAL PROFILE OF OPTIC NEURITIS - EXPERIENCE OF THE OPTIC NEURITIS TREATMENT TRIAL

被引：471

作者：

BECH, RW

机构：

[1] University of South Florida, Tampa, FL

[2] Data Coordinating Center, The George Washington University Biostatistics Center, Rockville, MD

[3] Visual Field Reading Center, University of California, Davis

[4] MRI Reading Center, University Diagnostics Institute, Tampa, Fla

[5] National Eye Institute, Bethesda, MD

[6] Cullen Eye Institute, Baylor College of Medicine, Houston, Tex

[7] Smith-Kettlewell Eye Research Institute, Pacific Presbyterian Medical Center, San Francisco, CA

[8] Duke University, Durham, NC

[9] University of Florida, Gainesville

[10] Center for Sight, Georgetown University, Washington, DC

[11] University of Illinois, Chicago

[12] University of Iowa, Iowa City

[13] Wills Eye Hospital, Philadelphia, PA

[14] Wilmer Eye Institute, The Johns Hopkins Hospital, Baltimore, MD

[15] Kellogg Eye Center, University of Michigan, Ann Arbor

[16] Michigan State University, East Lansing

[17] New York University, New York

[18] Devers Eye Institute, Good Samaritan Hospital, Portland, Ore

[19] University of Washington, Seattle

来源：

ARCHIVES OF OPHTHALMOLOGY | 1991年 / 109卷 / 12期

关键词：

D O I：

10.1001/archopht.1991.01080120057025

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The baseline characteristics of 448 elligible patients entered into the Optic Neuritis Treatment Trial are described in an effort to summarize the clinical profile of acute optic neuritis. A total of 77.2% of the patients were women. Mean age was 31.8 years. Paln accompanied the visual loss in 92.2% of cases. The optic disc appeared swollen in 35.3% of the patients and normal in 64.7%. A wide variety of visual field defects were present. Abnormalities in asymptomatic fellow eyes were noted, particularly on perimetry. Magnetic resonance imaging showed changes consistent with demyelination of the brain in 48.7% of the patients. Magnetic resonance imaging, serologic studies (such as the antinuclear antibody test and the fluorescent treponemal antibody absorption test), chest roentgenography, and lumbar puncture were of limited utility in defining a cause for visual loss other than optic neuritis associated with demyelinative disease.

引用

页码：1673 / 1678

页数：6

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