GLYCINE SITE ANTAGONISTS ABOLISH DOPAMINE D2 BUT NOT D1 RECEPTOR-MEDIATED CATALEPSY IN RATS

被引：33

作者：

KRETSCHMER, BD ^{[1
]}

WINTERSCHEID, B ^{[1
]}

DANYSZ, W ^{[1
]}

SCHMIDT, WJ ^{[1
]}

机构：

[1] MERZ & CO GMBH,DEPT PHARMACOL,FRANKFURT,GERMANY

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1994年 / 95卷 / 02期

关键词：

GLYCINE; NMDA; 7-CHLOROKYNURENATE; (R)-HA-966; HALOPERIDOL; SCH; 23390; DOPAMINE; D1; D2; CATALEPSY; PARKINSONS DISEASE;

D O I：

10.1007/BF01276431

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Catalepsy-a state of postural immobility (akinesia) with muscular rigidity (rigor)-and reduced locomotion in animals are behavioral deficits showing similarities with symptoms of Parkinson's disease (PD). The effects of the glycine site antagonists 7-chlorokynurenate and (R)-HA-966 on haloperidol- (D2 antagonist) and SCH 23390- (D1 antagonist) induced catalepsy and reduced locomotion are investigated in rats. Both antagonists dose-dependently counteract dopamine D2 receptor mediated catalepsy but they have no influence on locomotion. Neither 7-chlorokynurenate nor (R)-HA-966 has any effect on dopamine D1 receptor mediated catalepsy. This finding is surprising, since NMDA receptor antagonists counteract both, dopamine D1 and D2 receptor mediated catalepsy. D1 and D2 receptors are located on different populations of neurons. Thus, the present findings suggest that these different neuronal populations have different sensitivity for ligands binding at the glycine binding site of the NMDA receptor.

引用

页码：123 / 136

页数：14

共 40 条

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