FAMILIAL AUTOIMMUNE MYASTHENIA-GRAVIS

被引：31

作者：

BERGOFFEN, J

ZMIJEWSKI, CM

FISCHBECK, KH

机构：

[1] UNIV PENN,SCH MED,DEPT NEUROL,CLIN RES BLDG,ROOM 280,422 CURIE BLVD,PHILADELPHIA,PA 19104

[2] UNIV PENN,SCH MED,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104

[3] CHILDRENS HOSP PHILADELPHIA,DEPT HUMAN GENET & MOLEC BIOL,PHILADELPHIA,PA

来源：

NEUROLOGY | 1994年 / 44卷 / 03期

关键词：

D O I：

10.1212/WNL.44.3_Part_1.551

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe a family with parental consanguinity and five of 10 siblings affected by late-onset autoimmune myasthenia gravis. We propose a genetic mechanism as a predisposing factor in this family. Our analysis excludes the major histocompatibility complex, the beta subunit of the acetylcholine receptor, and the T-cell receptor alpha and beta subunits as candidate genes for the disorder in this family.

引用

页码：551 / 554

页数：4

共 10 条

[1]

ABDALLA JA, 1992, AM J HUM GENET, V51, P579

[2] CLINICAL, PATHOLOGICAL, HLA-ANTIGEN AND IMMUNOLOGICAL EVIDENCE FOR DISEASE HETEROGENEITY IN MYASTHENIA-GRAVIS [J].