FATTY REPLACEMENT OF BONE-MARROW AFTER RADIATION-THERAPY FOR HODGKIN DISEASE - QUANTIFICATION WITH CHEMICAL-SHIFT IMAGING

被引:15
作者
KAUCZOR, HU
DIETL, B
BRIX, G
JAROSCH, K
KNOPP, MV
VANKAICK, G
机构
[1] Department of Radiology, German Cancer Research Center, Heidelberg
[2] Department of Radiology, University of Mainz, Mainz, 6500
[3] Department of Radiotherapy, University of Heidelberg, Heidelberg
[4] Department of Radiotherapy, University of Regensburg, Regensburg
来源
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 04期
关键词
BONE MARROW; EFFECTS OF IRRADIATION ON; CHEMICAL SHIFT; FEMUR; PELVIS; RADIATIONS; INJURIOUS EFFECTS; COMPLICATIONS OF THERAPEUTIC RADIOLOGY; SPINE; TISSUE CHARACTERIZATION;
D O I
10.1002/jmri.1880030405
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The authors studied the long-term fatty replacement of bone marrow in 23 patients who had received radiation therapy for Hodgkin disease, with T1-weighted magnetic resonance imaging and quantitative chemical shift imaging. T1-weighted images revealed a mostly homogeneous high-signal-intensity pattern, in contrast to the hypointense pattern of nonirradiated marrow. The degree of fatty replacement was objectively assessed with chemical shift imaging, comparing patients to age-matched healthy volunteers. The authors found an increase in relative fat signal of 37% in the thoracic spine and 34% in the lumbar spine. The relative fat signal of nonirradiated pelvic and femoral marrow was decreased by 8%, indicating marrow reconversion. No radiation dose dependence was found in the range from 25 to 50 Gy. No signs of marrow regeneration were observed 15-126 months after radiation therapy. With chemical shift imaging, the degree of long-term radiogenic fatty replacement of the bone marrow can be quantified, confirming the lack of regeneration after radiation therapy for Hodgkin disease.
引用
收藏
页码:575 / 580
页数:6
相关论文
共 30 条
[1]  
Knospe WH, Blom J, Crosby WH, Regeneration of locally irradiated bone marrow. I. Dose dependent, long‐term changes in the rat, with particular emphasis upon the vascular and stromal reaction, Blood, 28, pp. 398-415, (1966)
[2]  
Sykes MP, Chu FCH, Savel H, Bonadonna G, Mathis H, Longterm effects of therapeutic irradiation upon bone marrow, Cancer, 17, pp. 1144-1148, (1964)
[3]  
Rubin P, Landman S, Mayer E, Keller B, Ciccio S, Bone marrow regeneration and extension after extended field irradiation in Hodgkin's disease, Cancer, 32, pp. 699-716, (1973)
[4]  
Vogler JB, Murphy WA, Bone marrow imaging, Radiology, 168, pp. 679-693, (1988)
[5]  
Daffner RH, Lupertin AR, Dash N, Deeb ZL, Sefczek R, Schapiro RL, MRI in the detection of malignant infiltration of bone marrow, AJR, 146, pp. 353-358, (1986)
[6]  
Dewes W, Ruhlmann J, Loos U, Et al., MR tomography in lymphatic and leukaemic bone infiltrations, ROFO, 147, pp. 654-661, (1987)
[7]  
Guckel F, Semmler W, Dohner H, Et al., MRI demonstration of bone marrow infiltration in malignant lymphoma, ROFO, 150, pp. 26-31, (1989)
[8]  
Smith SR, Williams CE, Davies JM, Edwards RHT, Bone marrow disorders: characterization with quantitative MR imaging, Radiology, 172, pp. 805-810, (1989)
[9]  
Casamassima F, Ruggiero C, Caramella D, Tinacci E, Villari N, Ruggiero M, Hematopoietic bone marrow recovery after radiation therapy: MRI evaluation, Blood, 73, pp. 1677-1681, (1989)
[10]  
Ramsey RG, Zacharias CE, MR imaging of the spine after radiation therapy: easily recognizable effects, AJR, 144, pp. 1131-1135, (1985)