COMPARISON OF ALBUMIN AND FIBRINOGEN BIOSYNTHESIS IN STIMULATED RATS AND CULTURED FETAL RAT HEPATOCYTES

被引：22

作者：

RUPP, RG

FULLER, GM

机构：

[1] The University of Texas Medical Branch Graduate School, Biomedical Sciences Department of Human Biological Chemistry and Genetics Galveston

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91733-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is presented that cultured fetal rat hepatocytes, when incubated with a crude leucocytic extract derived from rabbits undergoing an inflammatory response, show a marked increase in fibrinogen production and a concomitant decrease in albumin production. Antibody binding to polyribosomes synthesizing fibrinogen and albumin shows the same inverse relationship in rats undergoing an artificially induced inflammatory response. These data demonstrate directly and unequivocally that during the acute phase (inflammatory) response, the biosynthesis of these two plasma proteins is inversely affected by a factor or factors acting directly on the liver. © 1979.

引用

页码：327 / 334

页数：8

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