DETERMINATION OF CLONAZEPAM IN HUMAN-PLASMA BY GAS CHROMATOGRAPHY NEGATIVE ION CHEMICAL IONIZATION MASS-SPECTROMETRY

被引：41

作者：

GARLAND, WA

MIN, BH

机构：

[1] Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 172卷 / APR期

关键词：

D O I：

10.1016/S0021-9673(00)90963-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Our previously reported gas chromatographic-mass spectrometric assay for clonazepam using possitive ion chemical ionization has been modified to employ negative ion chemical ionization. The sensitivity using this technique (< 0.1 ng/ml) is approximately twenty times better than the positive ion chemical ionization procedure with similar precision. The method was used to determine the clonazepam plasma concentration in one human for 96 h following a single 2-mg dose of clonazepam. © 1979.

引用

页码：279 / 286

页数：8

共 9 条

[1] PHARMACOKINETICS OF ANTICONVULSANT DRUG CLONAZEPAM EVALUATED FROM SINGLE ORAL AND INTRAVENOUS DOSES AND BY REPEATED ORAL-ADMINISTRATION [J].