NERVE GROWTH FACTOR-INDUCED NEURONAL DIFFERENTIATION IS ACCOMPANIED BY DIFFERENTIAL SPLICING OF BETA-AMYLOID PRECURSOR MESSENGER-RNAS IN THE PC12 CELL-LINE

被引：41

作者：

SMITH, CJ

WION, D

BRACHET, P

机构：

[1] INSERM U298, CHRU, Angers

来源：

MOLECULAR BRAIN RESEARCH | 1991年 / 10卷 / 04期

关键词：

BETA-AMYLOID PRECURSOR; PC12; NERVE GROWTH FACTOR; ALTERNATIVE RNA SPLICING; NEURONAL DIFFERENTIATION;

D O I：

10.1016/0169-328X(91)90095-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the neurotrophic factor nerve growth factor (NGF) on the expression of the beta-amyloid gene has been studied in the clonal nerve cell line PC12. The neuronal differentiation of PC12 cells in the presence of NGF was accompanied by a shift in the ratio of beta-amyloid precursor protein (APP) transcripts. In particular there was reduced expression of the transcript coding for the longest precursor form (APP770) and a concomitant increase in the shortest (APP695) transcript following NGF treatment.

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页码：351 / 354

页数：4

相关论文

共 32 条

[1] DIFFERENTIAL BRAIN EXPRESSION OF THE ALZHEIMERS AMYLOID PRECURSOR PROTEIN [J].

ANDERSON, JP ;

REFOLO, LM ;

WALLACE, W ;

MEHTA, P ;

KRISHNAMURTHI, M ;

GOTLIB, J ;

BIERER, L ;

HAROUTUNIAN, V ;

PERL, D ;

ROBAKIS, NK .

EMBO JOURNAL, 1989, 8 (12) :3627-3632

[2]

AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303

[3] LOCALIZATION OF AMYLOID BETA-PROTEIN MESSENGER-RNA IN BRAINS FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].

BAHMANYAR, S ;

HIGGINS, GA ;

GOLDGABER, D ;

LEWIS, DA ;

MORRISON, JH ;

WILSON, MC ;

SHANKAR, SK ;

GAJDUSEK, DC .

SCIENCE, 1987, 237 (4810) :77-80

[4] A NOVEL MESSENGER-RNA OF THE A4-AMYLOID PRECURSOR GENE CODING FOR A POSSIBLY SECRETED PROTEIN [J].

DESAUVAGE, F ;

OCTAVE, JN .

SCIENCE, 1989, 245 (4918) :651-653

[5] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[6] EXPRESSION OF BETA-AMYLOID PROTEIN-PRECURSOR MESSENGER-RNAS - RECOGNITION OF A NOVEL ALTERNATIVELY SPLICED FORM AND QUANTITATION IN ALZHEIMERS-DISEASE USING PCR [J].

GOLDE, TE ;

ESTUS, S ;

USIAK, M ;

YOUNKIN, LH ;

YOUNKIN, SG .

NEURON, 1990, 4 (02) :253-267

[7] ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR [J].

GREENE, LA ;

TISCHLER, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) :2424-2428

[8] DIFFERENTIAL REGULATION OF AMYLOID-BETA-PROTEIN MESSENGER-RNA EXPRESSION WITHIN HIPPOCAMPAL NEURONAL SUBPOPULATIONS IN ALZHEIMER-DISEASE [J].

HIGGINS, GA ;

LEWIS, DA ;

BAHMANYAR, S ;

GOLDGABER, D ;

YOUNG, WG ;

WILSON, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (04) :1297-1301

[9] ALTERED LEVELS OF AMYLOID PROTEIN-PRECURSOR TRANSCRIPTS IN THE BASAL FOREBRAIN OF BEHAVIORALLY IMPAIRED AGED RATS [J].

HIGGINS, GA ;

OYLER, GA ;

NEVE, RL ;

CHEN, KS ;

GAGE, FH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3032-3036

[10] RELATION OF NEURONAL APP-751/APP-695 MESSENGER-RNA RATIO AND NEURITIC PLAQUE DENSITY IN ALZHEIMERS-DISEASE [J].

JOHNSON, SA ;

MCNEILL, T ;

CORDELL, B ;

FINCH, CE .

SCIENCE, 1990, 248 (4957) :854-857

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